WELCOMEWelcome to Zhu Lab

We are the Laboratory for Mass Spectrometry and Metabolomics, affiliated with Interdisciplinary Research Center on Biology and Chemistry (IRCBC), Shanghai Institute of Organic Chemistry (SIOC), Chinese Academy of Sciences (CAS).
Metabolites, the chemical entities that are transformed during metabolism, provide a functional readout of cellular biochemistry. With mass spectrometry based metabolomics technique, thousands of metabolites can now be quantitatively measured from minimal amounts of biological material, which…


Large-scale metabolite annotation is a challenge in liquid chromatogram-mass spectrometry (LC-MS)-based untargeted metabolomics.


The metabolome includes not just known but also unknown metabolites; however, metabolite annotation remains the bottleneck in untargeted metabolomics. Ion mobility – mass spectrometry (IM-MS) has emerged as a promising technology by providing multi-dimensional characterizations of metabolites

Global Stable-isotope Tracing Metabolomics Reveals System-wide Metabolic Alternations in Aging Drosophila

R. Wang, Y. Yin, J. Li, H. Wang, W. Lv, Y. Gao, T. Wang, Y. Zhong, Z. Zhou, Y. Cai, X. Su, N. Liu*, and Z.-J. Zhu*

Nature Communications, 2022, 13: 3518.

Trapped Ion Mobility Spectrometry-Mass Spectrometry Improves the Coverage and Accuracy of Four-dimensional Untargeted Lipidomics

X. Chen†, Y. Yin†, M. Luo, Z. Zhou, Y. Cai*, and Z.-J. Zhu*

Analytica Chimica Acta, 2022, 1210: 339886.

RIPK1 Regulates Starvation Resistance by Modulating Aspartate Catabolism

X. Mei†, Y. Guo†, Z. Xie†, Y. Zhong, X. Wu, D. Xu, Y. Li, N. Liu, and Z.-J. Zhu*

Nature Communications, 2021, 12: 6144.